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study published in Nature Medicine

Institute researchers Advanced Science and Technology (KAIST) in Daejeon (South Korea) have identified a version specific gene encoding a protein GIT1 in the brain that is linked to the disorder attention deficit hyperactivity (ADHD) in humans. The results of their work is published in the online edition of the journal Nature Medicine.

The ADHD is characterized by hyperactivity and deficits in learning and memory, affecting both children and adults. The scientists, led by Kim Eunjoon have discovered that a polymorphism of GIT1, a version of the gene, increases the risk of ADHD in humans, probably by decreasing GIT1 protein expression.

Mice deficient in GIT1 protein exhibited behaviors similar to those of ADHD, relieved by psychostimulant drugs used to treat human ADHD. The animals also showed deficits in inhibitory neurotransmission, suggesting that this could be one mechanism by which behavioral deficits seen in individuals with ADHD with the disease linked to polymorphism in GIT1. Source:

http://www.europapress.es/salud/noticia-identifican-variante-genetica-asociada-trastorno-hiperactividad-deficit-atencion-20110418104348.html